Bempedoic Acid Impurities

Bempedoic acid is first-in-class adenosine triphosphate-citrate lyase (ACL) inhibitor used once a day for reducing LDL cholesterol levels in statin-refractory patients. It was developed by Esperion Therapeutics Inc. and approved by the FDA on February 21, 2020. A combination product of bempedoic acid and ezetimibe was approved on February 26, 2020 for increased control of LDL cholesterol levels in patients experiencing refractory elevations despite previous statin treatment. Bempedoic Acid Impurities are primarily used as a reference standard in the pharmaceutical industry for analytical method development and validation to detect and quantify trace levels of this potential contaminant (a nitrosamine impurity) during the manufacturing process of the Bempedoic Acid. It can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Bempedoic Acid

Created: 2/21/2025
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Anastrozole Impurity A
Impurity Name: Anastrozole Impurity A
IUPAC Name: 2,2'-[5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]bis(2-methylpropanenitrile)
CAS Number: 1215780-15-6
Molecular Formula: C16H17N5
Molecular Weight: 279.34
Status: available
Anastrozole Impurity B
Impurity Name: Anastrozole Impurity B
IUPAC Name: 2,2',2''-[5,5'-(1H-1,2,4-triazol-1-ylmethyl)-1,3-phenylene]tris(2-methylpropanenitrile)
CAS Number: 1216898-82-6
Molecular Formula: C30H31N9
Molecular Weight: 517.63
Status: available
Anastrozole Impurity D
Impurity Name: Anastrozole Impurity D
IUPAC Name: 4,5-dibromo-2-(2-methylpropanenitrile)-1-(2-methylpropanenitrile)benzene
CAS Number: 1027160-12-8
Molecular Formula: C15H16Br2N2
Molecular Weight: 384.11
Status: available
Anastrozole Impurity I
Impurity Name: Anastrozole Impurity I
IUPAC Name: 4-chloro-2,6-bis(2-methylpropanenitrile)benzene
CAS Number: 120511-91-3
Molecular Formula: C15H17ClN2
Molecular Weight: 260.76
Status: available
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