Zolmitriptan Impurities
Zolmitriptan is a member of the triptan class of 5-hydroxytryptamine (5-HT)1B/1D/(1F) receptor agonists used to treat acute migraine. Sumatriptan was the first triptan to be developed, but had poor oral bioavailability and lipophilicity. This led to the development of second-generation triptans, including almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, and zolmitriptan. Triptans can be administered alone or in combination with an NSAID like naproxen, and represent the current "gold standard" for acute migraine treatment. Zolmitriptan was first approved by the FDA for sale by Zeneca Pharmaceuticals under the trade name Zomig® on November 25, 1997. It is currently available in both tablet and nasal spray forms. Zolmitriptan Impurities are primarily used as a reference standard in the pharmaceutical industry for analytical method development and validation to detect and quantify trace levels of this potential contaminant during the manufacturing process of the Zolmitriptan. It can be used for the analytical method development, method validation (AMV), Quality Controlled (QC) application for Abbreviated New Drug Application (ANDA) or during commercial production of Zolmitriptan.
| Image | Details |
|---|---|
 | Impurity Name: Zolmitriptan Amine Impurity IUPAC Name: 3-[2-(1H-indol-3-yl)ethyl]-1,3-oxazolidin-2-one-4-amine CAS Number: 139264-15-6 Molecular Formula: C14H17N3O2 Molecular Weight: 259.30 Status: available |
 | Impurity Name: Zolmitriptan N-Oxide Impurity IUPAC Name: 3-[2-(1H-indol-3-yl)ethyl]-1,3-oxazolidin-2-one-4-amine N-oxide CAS Number: 251451-30-6 Molecular Formula: C16H21N3O3 Molecular Weight: 303.36 Status: available |
 | Impurity Name: Zolmitriptan N-Desmethyl Impurity IUPAC Name: 3-[2-(1H-indol-3-yl)ethyl]-1,3-oxazolidin-2-one CAS Number: 139264-35-0 Molecular Formula: C15H19N3O2 Molecular Weight: 273.33 Status: available |
 | Impurity Name: Zolmitriptan Related Compound G IUPAC Name: (4R)-4-(4-aminobenzyl)-1,3-oxazolidin-2-one CAS Number: 152305-23-2 Molecular Formula: C10H12N2O2 Molecular Weight: 192.21 Status: available |